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This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse Granzyme B. The Mouse Granzyme B ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs) and natural killer cells (NK cells). It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells. Granzyme B has also more recently found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells. Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling. Elevated levels of granzyme B are also implicated in a number of autoimmune diseases, several skin diseases, and type 1 diabetes.
